Caregivers are the biggest support system for many patients and are often working adults who provide care in their off-work hours to family members, spouses or children. Caregivers also look like the elderly providing care for a spouse, parents of children with disabilities, and home health aides. It’s these responsibilities that they already face in their daily routines that are making it difficult get participants enrolled to in-clinic site visits and typically, traditional trial designs create competing priorities for caregivers and their patients.